Pub. Date : 2014 Jun 25
PMID : 24964992
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We identified prostaglandin E2 (PGE2) as a soluble tumor-derived angiogenic factor associated with VEGF-independent angiogenesis. | Dinoprostone | vascular endothelial growth factor A | Homo sapiens |
| 2 | We identified prostaglandin E2 (PGE2) as a soluble tumor-derived angiogenic factor associated with VEGF-independent angiogenesis. | Dinoprostone | vascular endothelial growth factor A | Homo sapiens |
| 3 | PGE2 production in preclinical breast and colon cancer models was tightly controlled by cyclooxygenase-2 (COX-2) expression, and COX-2 inhibition augmented VEGF pathway blockade to suppress angiogenesis and tumor growth, prevent metastasis, and increase overall survival. | Dinoprostone | vascular endothelial growth factor A | Homo sapiens |
| 4 | These results demonstrate the importance of the COX-2/PGE2 pathway in mediating resistance to VEGF pathway blockade and could aid in the rapid development of more efficacious anticancer therapies. | Dinoprostone | vascular endothelial growth factor A | Homo sapiens |