Pub. Date : 2015 Oct
PMID : 24962868
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | 6-Shogaol exerts anti-proliferative and pro-apoptotic effects through the modulation of STAT3 and MAPKs signaling pathways. | shogaol | signal transducer and activator of transcription 3 | Homo sapiens |
| 2 | Because the aberrant activation of STAT3 and MAPKs have been associated with regulation of proliferation, invasion, and metastasis of tumors, we hypothesized that 6SG modulates the activation of STAT3 and MAPKs activation in tumor cells. | shogaol | signal transducer and activator of transcription 3 | Homo sapiens |
| 3 | Because the aberrant activation of STAT3 and MAPKs have been associated with regulation of proliferation, invasion, and metastasis of tumors, we hypothesized that 6SG modulates the activation of STAT3 and MAPKs activation in tumor cells. | shogaol | signal transducer and activator of transcription 3 | Homo sapiens |
| 4 | We found that 6SG strongly inhibited constitutive phosphorylation of STAT3 through inhibition of the activation of upstream JAK2 and c-Src kinases and nuclear translocation of STAT3 on both MDA-MB231 and DU145 cells. | shogaol | signal transducer and activator of transcription 3 | Homo sapiens |
| 5 | We found that 6SG strongly inhibited constitutive phosphorylation of STAT3 through inhibition of the activation of upstream JAK2 and c-Src kinases and nuclear translocation of STAT3 on both MDA-MB231 and DU145 cells. | shogaol | signal transducer and activator of transcription 3 | Homo sapiens |
| 6 | 6SG induced apoptosis as characterized by cleavage of PARP, accumulation of cells in subG1 phase, positive Annexin V binding, down-regulation of STAT3-regulated proteins, and activation of caspase-8, -9, -3 in both MDA-MB231 cells. | shogaol | signal transducer and activator of transcription 3 | Homo sapiens |
| 7 | Compared with other analogues of 6SG, such as 6-gingerol (6G), 8-gingerol (8G), and 10-gingerol (10G), 6SG was found to be the most potent blocker of STAT3 activation. | shogaol | signal transducer and activator of transcription 3 | Homo sapiens |
| 8 | Compared with other analogues of 6SG, such as 6-gingerol (6G), 8-gingerol (8G), and 10-gingerol (10G), 6SG was found to be the most potent blocker of STAT3 activation. | shogaol | signal transducer and activator of transcription 3 | Homo sapiens |
| 9 | As compared to the vehicle control, 6SG also suppressed the expression of STAT3-regulated gene products such as Bcl-2, Bcl-xL, and Survivin in tumor tissues. | shogaol | signal transducer and activator of transcription 3 | Homo sapiens |