Title : Ribavirin uptake into human hepatocyte HHL5 cells is enhanced by interferon-α via up-regulation of the human concentrative nucleoside transporter (hCNT2).

Pub. Date : 2014 Sep 2

PMID : 24957263






3 Functional Relationships(s)
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Sentence
Compound Name
Protein Name
Organism
1 Ribavirin uptake into human hepatocyte HHL5 cells is enhanced by interferon-alpha via up-regulation of the human concentrative nucleoside transporter (hCNT2). Ribavirin solute carrier family 28 member 2 Homo sapiens
2 hCNT2 is the best candidate to mediate ribavirin uptake into hepatocytes due to its high-affinity for purines and its capacity to concentrate its substrates intracellularly. Ribavirin solute carrier family 28 member 2 Homo sapiens
3 hCNT2 activity up-regulation was associated with increased ribavirin accumulation into cells. Ribavirin solute carrier family 28 member 2 Homo sapiens