Title : Selective potent restriction of P450b- but not P450e-dependent 7,12-dimethylbenz[a]anthracene metabolism by the microsomal environment.

Pub. Date : 1989 Apr

PMID : 2494942






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 A unique regioselectivity difference between cytochromes P450b and P450e for the metabolism of 7,12-dimethylbenz[a]anthracene (DMBA) and a genetic deficiency in P450e expression in the Marshall (M520/N) rat strain have been exploited to determine the microsomal contributions of the respective forms toward the metabolism of DMBA. anthracene cytochrome P450, family 2, subfamily b, polypeptide 1 Rattus norvegicus