Title : Calcineurin-mediated YB-1 dephosphorylation regulates CCL5 expression during monocyte differentiation.

Pub. Date : 2014 Aug 1

PMID : 24947514






3 Functional Relationships(s)
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Compound Name
Protein Name
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1 We previously demonstrated that YB-1 protein is transiently up-regulated during monocyte/macrophage differentiation evidenced in monocytic cells (THP-1 cells) that were differentiated using phorbol myristate acetate (PMA). Tetradecanoylphorbol Acetate Y-box binding protein 1 Homo sapiens
2 We previously demonstrated that YB-1 protein is transiently up-regulated during monocyte/macrophage differentiation evidenced in monocytic cells (THP-1 cells) that were differentiated using phorbol myristate acetate (PMA). Tetradecanoylphorbol Acetate Y-box binding protein 1 Homo sapiens
3 Here we provide evidence that YB-1 phosphorylation, specifically at its serine residue 102 (Ser-102), increases early on in THP-1 cells following PMA treatment as well as in differentiated primary human monocytes. Tetradecanoylphorbol Acetate Y-box binding protein 1 Homo sapiens