Title : B-Raf regulation of integrin α4β1-mediated resistance to shear stress through changes in cell spreading and cytoskeletal association in T cells.

Pub. Date : 2014 Aug 15

PMID : 24936068






1 Functional Relationships(s)
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1 We show that chemical inhibition of RAF by sorafenib or shRNA-mediated knockdown of B-Raf reduces T cell resistance to shear stress to alpha4beta1 integrin ligands vascular cell adhesion molecule 1 (VCAM-1) and fibronectin, whereas inhibition of MEK/ERK by U0126 had no effect. Sorafenib zinc fingers and homeoboxes 2 Homo sapiens