Title : Applying caspase-1 inhibitors for inflammasome assays in human whole blood.

Pub. Date : 2014 Sep

PMID : 24925806






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 We demonstrate ac-YVAD-cmk is a specific caspase-1 inhibitor resulting in pronounced decreases in IL-1beta and less suppression of TNFalpha, IL-6 and IL-8, while pan-caspase inhibitor, z-VAD-fmk, only weakly suppressed Il-1beta while acting strongly on the other three cytokines. ac-yvad caspase 1 Homo sapiens
2 We demonstrate ac-YVAD-cmk is a specific caspase-1 inhibitor resulting in pronounced decreases in IL-1beta and less suppression of TNFalpha, IL-6 and IL-8, while pan-caspase inhibitor, z-VAD-fmk, only weakly suppressed Il-1beta while acting strongly on the other three cytokines. ac-yvad caspase 1 Homo sapiens