Title : Applying caspase-1 inhibitors for inflammasome assays in human whole blood.

Pub. Date : 2014 Sep

PMID : 24925806






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1 While several inhibitors are available for caspase-1 blocking experiments, in this study we show effects of two commonly used caspase inhibitors: z-VAD-fmk and ac-YVAD-cmk on secretion of pro-inflammatory cytokines: IL-1beta, TNFalpha, IL-8 and IL-6 in whole blood stimulated with LPS. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone tumor necrosis factor Homo sapiens