Pub. Date : 2014
PMID : 24917821
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | VDR and the p53/p63/p73 proteins all function typically as receptors or sensors that turn into transcriptional regulators upon stimulus, with the main difference being that the nuclear VDR is activated as a transcription factor after binding its naturally occurring ligand 1,25-dihydroxyvitamin D with high affinity while the p53 family of transcription factors, mostly in the nucleoplasm, responds to a large number of alterations in cell homeostasis commonly referred to as stress. | 1,25-dihydroxyvitamin D | transformation related protein 53, pseudogene | Mus musculus |
| 2 | VDR and the p53/p63/p73 proteins all function typically as receptors or sensors that turn into transcriptional regulators upon stimulus, with the main difference being that the nuclear VDR is activated as a transcription factor after binding its naturally occurring ligand 1,25-dihydroxyvitamin D with high affinity while the p53 family of transcription factors, mostly in the nucleoplasm, responds to a large number of alterations in cell homeostasis commonly referred to as stress. | 1,25-dihydroxyvitamin D | transformation related protein 53, pseudogene | Mus musculus |
| 3 | UV irradiation-surviving cells show significant reductions in thymine dimers in the presence of 1,25-dihydroxyvitamin D that are associated with increased nuclear p53 protein expression, and significantly reduced NO products. | 1,25-dihydroxyvitamin D | transformation related protein 53, pseudogene | Mus musculus |