Title : Disulfiram targeting lymphoid malignant cell lines via ROS-JNK activation as well as Nrf2 and NF-kB pathway inhibition.

Pub. Date : 2014 Jun 11

PMID : 24915933






7 Functional Relationships(s)
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1 RESULTS: In combination with a low concentration (1 muM) of Cu2+, DS induced cytotoxicity in Raji cells with an IC50 of 0.085 +- 0.015 muM and in Molt4 cells with an IC50 of 0.435 +- 0.109 muM. Disulfiram latexin Homo sapiens
2 RESULTS: In combination with a low concentration (1 muM) of Cu2+, DS induced cytotoxicity in Raji cells with an IC50 of 0.085 +- 0.015 muM and in Molt4 cells with an IC50 of 0.435 +- 0.109 muM. Disulfiram latexin Homo sapiens
3 RESULTS: In combination with a low concentration (1 muM) of Cu2+, DS induced cytotoxicity in Raji cells with an IC50 of 0.085 +- 0.015 muM and in Molt4 cells with an IC50 of 0.435 +- 0.109 muM. Disulfiram latexin Homo sapiens
4 After exposure to DS (3.3 muM)/Cu (1 muM) for 24 hours, apoptosis was detected in 81.03 +- 7.91% of Raji cells. Disulfiram latexin Homo sapiens
5 After exposure to DS (3.3 muM)/Cu (1 muM) for 24 hours, apoptosis was detected in 81.03 +- 7.91% of Raji cells. Disulfiram latexin Homo sapiens
6 DS/Cu induced significant apoptosis in a concentration-dependent manner with the highest apoptotic proportion (DS/Cu: 89.867 +- 4.69%) at a concentration of 2 muM in Molt4 cells. Disulfiram latexin Homo sapiens
7 DS/Cu induced significant apoptosis in a concentration-dependent manner with the highest apoptotic proportion (DS/Cu: 89.867 +- 4.69%) at a concentration of 2 muM in Molt4 cells. Disulfiram latexin Homo sapiens