Pub. Date : 2014 Aug
PMID : 24912678
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | RhoB promotes gammaH2AX dephosphorylation and DNA double-strand break repair. | gammah2ax | ras homolog family member B | Homo sapiens |
| 2 | RhoB-deficient cells fail to dephosphorylate gammaH2AX following camptothecin removal and show reduced efficiency of DSB repair by homologous recombination. | gammah2ax | ras homolog family member B | Homo sapiens |
| 3 | Thus, we propose that DSBs activate a Chk2-HuR-RhoB pathway that promotes PP2A-mediated dephosphorylation of gammaH2AX and DSB repair. | gammah2ax | ras homolog family member B | Homo sapiens |