Title : Omega-3 free fatty acids suppress macrophage inflammasome activation by inhibiting NF-κB activation and enhancing autophagy.

Pub. Date : 2014

PMID : 24911523






5 Functional Relationships(s)
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1 The omega-3 (omega3) fatty acid docosahexaenoic acid (DHA) can suppress inflammation, specifically IL-1beta production through poorly understood molecular mechanisms. Docosahexaenoic Acids interleukin 1 beta Mus musculus
2 The omega-3 (omega3) fatty acid docosahexaenoic acid (DHA) can suppress inflammation, specifically IL-1beta production through poorly understood molecular mechanisms. Docosahexaenoic Acids interleukin 1 beta Mus musculus
3 Here, we show that DHA reduces macrophage IL-1beta production by limiting inflammasome activation. Docosahexaenoic Acids interleukin 1 beta Mus musculus
4 Exposure to DHA reduced IL-1beta production by ligands that stimulate the NLRP3, AIM2, and NAIP5/NLRC4 inflammasomes. Docosahexaenoic Acids interleukin 1 beta Mus musculus
5 DHA also reduced IL-1beta levels by enhancing autophagy in the cells. Docosahexaenoic Acids interleukin 1 beta Mus musculus