Title : Design, Synthesis, and Antitumor Activity of 4-Halocolchicines and Their Pro-drugs Activated by Cathepsin B.

Pub. Date : 2011 May 12

PMID : 24900316

1 Functional Relationships(s)
Compound Name
Protein Name
1 Further, utilizing the 4-substituted colchicines, we prepared pro-drugs having a dipeptide side chain and demonstrated that these pro-drugs were activated by cathepsin B, an enzyme overexpressed in tumor cells, and exhibited selective toxicity to the tumor cells. Dipeptides cathepsin B Homo sapiens