Title : Novel pyridyl- or isoquinolinyl-substituted indolines and indoles as potent and selective aldosterone synthase inhibitors.

Pub. Date : 2014 Jun 26

PMID : 24899257






1 Functional Relationships(s)
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1 Among them, compounds 14 and 23 showed good selectivity over the highly homologous CYP11B1, with selectivity factors (SF = IC50 CYP11B1/IC50 CYP11B2) around 170; thus, they are superior to fadrozole and LCI699 (SFs < 15). Fadrozole cytochrome P450 family 11 subfamily B member 1 Homo sapiens