Pub. Date : 2014 Oct
PMID : 24895437
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Atorvastatin reduced HMGCoA-R enzymatic activity and intracellular cholesterol synthesis in vitro; however, inflammatory stress weakened these suppressive effects. | Atorvastatin | 3-hydroxy-3-methylglutaryl-CoA reductase | Homo sapiens |
| 2 | Atorvastatin at concentrations of 15 microM inhibited HMGCoA-R activity by 50% (IC50) in HMCs, but the same concentration in the presence of interleukin (IL)-1beta resulted in only 30% inhibition of HMGCoA-R activity in HMCs. | Atorvastatin | 3-hydroxy-3-methylglutaryl-CoA reductase | Homo sapiens |
| 3 | Atorvastatin at concentrations of 15 microM inhibited HMGCoA-R activity by 50% (IC50) in HMCs, but the same concentration in the presence of interleukin (IL)-1beta resulted in only 30% inhibition of HMGCoA-R activity in HMCs. | Atorvastatin | 3-hydroxy-3-methylglutaryl-CoA reductase | Homo sapiens |