Title : Structure-based design, synthesis, and biological evaluation of isatin derivatives as potential glycosyltransferase inhibitors.

Pub. Date : 2014 Dec

PMID : 24890564






1 Functional Relationships(s)
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1 Structure-based virtual screening of about 3,000,000 commercially available compounds against the crystal structure of the glycosyltransferase (GT) domain of the Staphylococcus aureus penicillin-binding protein 2 (S. aureus PBP2) resulted in identification of an isatin derivative, 2-(3-(2-carbamimidoylhydrazono)-2-oxoindolin-1-yl)-N-(m-tolyl)acetamide (4) as a novel potential GT inhibitor. Isatin AT695_RS10295 Staphylococcus aureus