Title : Tumor-associated macrophage-derived IL-6 and IL-8 enhance invasive activity of LoVo cells induced by PRL-3 in a KCNN4 channel-dependent manner.

Pub. Date : 2014 May 10

PMID : 24885636






3 Functional Relationships(s)
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1 Furthermore, cytokines that were secreted by TAMs, such as IL-6 and IL-8, were also significantly increased. tams C-X-C motif chemokine ligand 8 Homo sapiens
2 This response was attenuated by treating TAMs with the KCNN4 channel-specific inhibitor, 1-[(2-chlorophenyl) diphenylmethyl]-1H-pyrazole (TRAM-34), which suggested that KCNN4 channels may be involved in inducing the secretion of IL-6 and IL-8 by TAMs and improving CRC cell invasiveness. tams C-X-C motif chemokine ligand 8 Homo sapiens
3 CONCLUSIONS: Our findings suggested that TAMs participate in the metastasis of CRC induced by PRL-3 through the TNF-alpha mediated secretion of IL-6 and IL-8 in a paracrine manner. tams C-X-C motif chemokine ligand 8 Homo sapiens