Pub. Date : 2014 Apr 30
PMID : 24884875
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Cisplatin-resistant cells in malignant pleural mesothelioma cell lines show ALDH(high)CD44(+) phenotype and sphere-forming capacity. | Cisplatin | CD44 molecule (Indian blood group) | Homo sapiens |
| 2 | At the transcript level, the cisplatin + DEAB-resistant cells showed upregulated mRNA expression levels for ALDH1A2, ALDH1A3 isozymes and CD44 indicating the involvement of these markers in conferring chemoresistance in both ALDH(high) and ALDH(low) fractions of the three MPM cell lines. | Cisplatin | CD44 molecule (Indian blood group) | Homo sapiens |
| 3 | CONCLUSIONS: Our study shows that ALDH(high) CD44(+) cells are implicated in conveying tolerance to cisplatin in the three MPM cell lines. | Cisplatin | CD44 molecule (Indian blood group) | Homo sapiens |