Pub. Date : 2014 Aug
PMID : 24880753
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Desipramine was selected as a model drug because it is mainly metabolized by CYP2D6, which is inhibited by almorexant in vitro. | Desipramine | cytochrome P450 family 2 subfamily D member 6 | Homo sapiens |
| 2 | Almorexant increased the exposure to desipramine 3.7-fold, suggesting that almorexant is a moderate inhibitor of desipramine metabolism through inhibition of CYP2D6. | Desipramine | cytochrome P450 family 2 subfamily D member 6 | Homo sapiens |
| 3 | Almorexant increased the exposure to desipramine 3.7-fold, suggesting that almorexant is a moderate inhibitor of desipramine metabolism through inhibition of CYP2D6. | Desipramine | cytochrome P450 family 2 subfamily D member 6 | Homo sapiens |