Title : Estrogen defines the dorsal-ventral limit of VEGF regulation to specify the location of the hemogenic endothelial niche.

Pub. Date : 2014 May 27

PMID : 24871948






1 Functional Relationships(s)
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1 Here, we report that 17beta-estradiol (E2) influences production of runx1+ HSPCs in the AGM region by antagonizing VEGF signaling and subsequent assignment of hemogenic endothelial (HE) identity. Estradiol vascular endothelial growth factor A Homo sapiens