Title : UPC2A is required for high-level azole antifungal resistance in Candida glabrata.

Pub. Date : 2014 Aug

PMID : 24867980






1 Functional Relationships(s)
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1 We hypothesized that due to the global role for Upc2 in sterol biosynthesis in S. cerevisiae and C. albicans, disruption of UPC2A would enhance the activity of fluconazole in both azole-susceptible dose-dependent (SDD) and -resistant C. glabrata clinical isolates. Sterols Upc2p Saccharomyces cerevisiae S288C