Title : The discovery of Polo-like kinase 4 inhibitors: design and optimization of spiro[cyclopropane-1,3'[3H]indol]-2'(1'H).ones as orally bioavailable antitumor agents.

Pub. Date : 2015 Jan 8

PMID : 24867403






1 Functional Relationships(s)
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1 Optimization of this new cyclopropane-linked series was based on a computational model of a PLK4 X-ray structure and SAR attained from the analogous alkenelinked series. cyclopropane sarcosine dehydrogenase Homo sapiens