Title : CXCL12/CXCR4 axis confers adriamycin resistance to human chronic myelogenous leukemia and oroxylin A improves the sensitivity of K562/ADM cells.

Pub. Date : 2014 Aug 1

PMID : 24858801






2 Functional Relationships(s)
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1 Moreover, the sensitivity enhancement of oroxylin A was demonstrated by decreasing the expression of CXCR4 at both protein and mRNA levels, via PI3K/Akt/NF-kappaB pathway and triggering the apoptosis pathway in vitro. 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one C-X-C motif chemokine receptor 4 Homo sapiens
2 In conclusion, all these results showed that oroxylin A improved the sensitivity of K562/ADM cells by increasing apoptosis in leukemic cells and decreasing the expression of CXCR4 and PI3K/Akt/NF-kappaB pathway, and probably served as a most promising agent for CML treatment. 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one C-X-C motif chemokine receptor 4 Homo sapiens