Pub. Date : 2014 Jul 15
PMID : 24853984
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Hirsutenone reduces deterioration of tight junction proteins through EGFR/Akt and ERK1/2 pathway both converging to HO-1 induction. | hirsutenone | mitogen-activated protein kinase 3 | Mus musculus |
| 2 | Hirsutenone-mediated protection against the loss of ZO-1 depends on the activation of both ERK1/2 and Akt signaling pathways. | hirsutenone | mitogen-activated protein kinase 3 | Mus musculus |
| 3 | Hirsutenone increased heme oxygenase-1 (HO-1) expression through both EGFR/Akt- and ERK1/2-dependent pathways, contributing to the protective effects against TJ dysfunction. | hirsutenone | mitogen-activated protein kinase 3 | Mus musculus |
| 4 | Taken together, our results demonstrate that hirsutenone reverse disordered intestinal permeability by activating EGFR/Akt and ERK1/2 pathways, which are involved in the regulation of HO-1 expression. | hirsutenone | mitogen-activated protein kinase 3 | Mus musculus |