Pub. Date : 2014
PMID : 24852948
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | This study was conducted to test the hypothesis that EGCG was able to inhibit tumor necrosis factor-alpha (TNF-alpha)-induced production of monocyte chemoattractant protein-1 (MCP-1) in human umbilical vein endothelial cells (HUVECs) and investigated the underlying molecular mechanisms. | epigallocatechin gallate | C-C motif chemokine ligand 2 | Homo sapiens |
| 2 | This study was conducted to test the hypothesis that EGCG was able to inhibit tumor necrosis factor-alpha (TNF-alpha)-induced production of monocyte chemoattractant protein-1 (MCP-1) in human umbilical vein endothelial cells (HUVECs) and investigated the underlying molecular mechanisms. | epigallocatechin gallate | C-C motif chemokine ligand 2 | Homo sapiens |
| 3 | METHODS: The inhibitory effect of EGCG on TNF-alpha-induced expression of MCP-1 was measured using ELISA and RT-qPCR. | epigallocatechin gallate | C-C motif chemokine ligand 2 | Homo sapiens |
| 4 | RESULTS: EGCG significantly suppressed the TNF-alpha-induced protein and mRNA expression of MCP-1. | epigallocatechin gallate | C-C motif chemokine ligand 2 | Homo sapiens |
| 5 | In addition, the 67-kD laminin receptor (67LR) was involved in EGCG-mediated suppression of MCP-1 generation. | epigallocatechin gallate | C-C motif chemokine ligand 2 | Homo sapiens |
| 6 | CONCLUSION: EGCG suppresses TNF-alpha-induced MCP-1 expression in HUVECs. | epigallocatechin gallate | C-C motif chemokine ligand 2 | Homo sapiens |