Title : Synthesis and structure-activity relationship of cyclopentenone oximes as novel inhibitors of the production of tumor necrosis factor-α.

Pub. Date : 2014 Jul 1

PMID : 24852119






1 Functional Relationships(s)
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1 3-Alkyl-2-aryl-2-cyclopenten-1-one oxime derivatives (1) were studied as a novel class of inhibitors of tumor necrosis factor alpha (TNF-alpha) with regard to synthesis and in vitro SAR inhibition of TNF-alpha. 3-alkyl-2-aryl-2-cyclopenten-1-one oxime sarcosine dehydrogenase Homo sapiens