Pub. Date : 2014 May
PMID : 24849437
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | [Effect of quercetin on glioma cell U87 apoptosis and feedback regulation of MDM2-p53]. | Quercetin | tumor protein p53 | Homo sapiens |
| 2 | OBJECTIVE: To investigate the effect of quercetin on apoptosis and feedback regulation of MDM2-p53 in multiform glioblastoma U87 cells in vitro. | Quercetin | tumor protein p53 | Homo sapiens |
| 3 | METHODS: U87 cells exposed to different concentrations of quercetin (50, 100, and 150 micromol/L) were examined with flow cytometry, RT-PCR and Western blotting for detecting the cell apoptosis, MDM2 mRNA expression, and p53 and caspase-3 expressions. | Quercetin | tumor protein p53 | Homo sapiens |
| 4 | Quercetin significantly increased the expressions of MDM2 mRNA and active caspase-3 protein but decreased the expression of p53 in the cells. | Quercetin | tumor protein p53 | Homo sapiens |
| 5 | CONCLUSION: Quercetin promotes the apoptosis of multiform glioblastoma U87 cells mediated by caspase-3 and influences the feedback balance of MDM2-p53. | Quercetin | tumor protein p53 | Homo sapiens |