Title : Docosahexaenoic acid prevents palmitate-induced activation of proteolytic systems in C2C12 myotubes.

Pub. Date : 2014 Aug

PMID : 24835079






3 Functional Relationships(s)
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1 This study investigated whether DHA prevents a palmitate-induced increase in proteolysis by restoring Akt/FoxO signaling. Docosahexaenoic Acids AKT serine/threonine kinase 1 Homo sapiens
2 DHA attenuated the effects of palmitate on Akt activation, FoxO3 localization and atrogene mRNAs. Docosahexaenoic Acids AKT serine/threonine kinase 1 Homo sapiens
3 These data indicate that palmitate induces myotube atrophy, at least in part, by activating multiple proteolytic systems and that DHA counters the catabolic effects of palmitate by restoring Akt/FoxO signaling. Docosahexaenoic Acids AKT serine/threonine kinase 1 Homo sapiens