Title : Pharmacological study of phospholipase A2-induced histamine release from rat peritoneal mast cells.

Pub. Date : 1989 Sep

PMID : 2482349






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1 Pharmacological study of phospholipase A2-induced histamine release from rat peritoneal mast cells. Histamine phospholipase A2 group IB Rattus norvegicus
2 The effect of some drugs on phospholipase A2 (PLA2)-induced histamine release from rat peritoneal mast cells was investigated. Histamine phospholipase A2 group IB Rattus norvegicus
3 The effect of some drugs on phospholipase A2 (PLA2)-induced histamine release from rat peritoneal mast cells was investigated. Histamine phospholipase A2 group IB Rattus norvegicus
4 PLA2 (Naja naja) caused the release of histamine from rat peritoneal mast cells in a dose related fashion. Histamine phospholipase A2 group IB Rattus norvegicus
5 The release of histamine by PLA2 was decreased by the removal of each of calcium and glucose from the reaction medium (Tyrode"s solution). Histamine phospholipase A2 group IB Rattus norvegicus
6 p-Bromophenacyl bromide and mepacrine, PLA2 inhibitors, inhibited the release of histamine caused by PLA2. Histamine phospholipase A2 group IB Rattus norvegicus
7 p-Bromophenacyl bromide and mepacrine, PLA2 inhibitors, inhibited the release of histamine caused by PLA2. Histamine phospholipase A2 group IB Rattus norvegicus
8 Cinnarizine and nifedipine, calcium channel blockers, and oxatomide, KC-404, tranilast and disodium cromoglycate, anti-allergic agents, also inhibited the PLA2-induced histamine release. Histamine phospholipase A2 group IB Rattus norvegicus
9 2, 3 and 4 h prior to the harvest of the mast cells, the amount of histamine released by PLA2 ex vivo was significantly decreased. Histamine phospholipase A2 group IB Rattus norvegicus