Title : SchA-p85-FAK complex dictates isoform-specific activation of Akt2 and subsequent PCBP1-mediated post-transcriptional regulation of TGFβ-mediated epithelial to mesenchymal transition in human lung cancer cell line A549.

Pub. Date : 2014 Aug

PMID : 24819169






1 Functional Relationships(s)
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1 Our experiments further elucidated that the adaptor protein SchA is phosphorylated at tyrosine residues following TGF-beta treatment, which initiated a signaling cascade resulting in the sequential recruitment of p85 subunit of PI3K and focal adhesion kinase (FAK). Tyrosine transforming growth factor beta 1 Homo sapiens