Title : Aryl hydrocarbon receptor repressor and TiPARP (ARTD14) use similar, but also distinct mechanisms to repress aryl hydrocarbon receptor signaling.

Pub. Date : 2014 May 6

PMID : 24806346






3 Functional Relationships(s)
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Protein Name
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1 TCDD increased AHRR mRNA levels and recruitment of AHRR to cytochrome P450 1A1 (CYP1A1) in MCF7 cells. Polychlorinated Dibenzodioxins aryl hydrocarbon receptor repressor Homo sapiens
2 TCDD increased AHRR mRNA levels and recruitment of AHRR to cytochrome P450 1A1 (CYP1A1) in MCF7 cells. Polychlorinated Dibenzodioxins aryl hydrocarbon receptor repressor Homo sapiens
3 Overexpression of TiPARP in AHRR(-/-) MEFs or AHRRDelta8, the active isoform of AHRR, in TiPARP(-/-) MEFs reduced TCDD-induced CYP1A1 mRNA levels, suggesting that they independently repress AHR. Polychlorinated Dibenzodioxins aryl hydrocarbon receptor repressor Homo sapiens