Title : Sulfuretin inhibits 6-hydroxydopamine-induced neuronal cell death via reactive oxygen species-dependent mechanisms in human neuroblastoma SH-SY5Y cells.

Pub. Date : 2014 Jul

PMID : 24801546






3 Functional Relationships(s)
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1 We also investigated whether sulfuretin specifically acts by inhibiting phosphorylation of mitogen-activated protein kinase (MAPK), phosphatidylinositol 3-kinase (PI3K)/Akt, and glycogen synthase kinase-3beta (GSK-3beta) as well as activation of the nuclear factor-kappa B (NF-kappaB) pathway. sulfuretin AKT serine/threonine kinase 1 Homo sapiens
2 Moreover, sulfuretin significantly attenuated 6-OHDA-induced phosphorylation of c-Jun N-terminal kinase (JNK), p38, extracellular signal-regulated kinase 1/2 (ERK 1/2) MAPKs, PI3K/Akt, and GSK-3beta. sulfuretin AKT serine/threonine kinase 1 Homo sapiens
3 The results of the current study provide the first evidence that sulfuretin protects SH-SY5Y cells against 6-OHDA-induced neuronal cell death, possibly through inhibition of phosphorylation of MAPK, PI3K/Akt, and GSK-3beta, which leads to mitochondrial protection, NF-kappaB modulations and subsequent suppression of apoptosis via ROS-dependent pathways. sulfuretin AKT serine/threonine kinase 1 Homo sapiens