Title : How slow RNA polymerase II elongation favors alternative exon skipping.

Pub. Date : 2014 May 22

PMID : 24793692






1 Functional Relationships(s)
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1 Using CFTR alternative exon 9 (E9) as a model, we show here that slowing down elongation can also cause exon skipping by promoting the recruitment of the negative factor ETR-3 onto the UG-repeat at E9 3" splice site, which displaces the constitutive splicing factor U2AF65 from the overlapping polypyrimidine tract. polypyrimidine CUGBP Elav-like family member 2 Homo sapiens