Title : ApoA-I or ABCA1 expression suppresses fatty acid synthesis by reducing 27-hydroxycholesterol levels.

Pub. Date : 2014 Aug

PMID : 24793484






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Overexpression of apoA-I in mice reduced hepatic lipid levels, 27-hydroxycholesterol levels, and the mRNA levels of fatty acid synthase and acetyl-CoA carboxylase 1. Hydroxycholesterols apolipoprotein A-I Mus musculus
2 These results suggest that expression of apoA-I or ABCA1 can reduce steatosis by decreasing lipid storage and modifying lipid transport in hepatocytes and may also inhibit fatty acid synthesis by decreasing 27-hydroxycholesterol levels. Hydroxycholesterols apolipoprotein A-I Mus musculus