Title : Mouse spermatocytes express CYP2E1 and respond to acrylamide exposure.

Pub. Date : 2014

PMID : 24788432






5 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 CYP2E1 metabolises acrylamide to glycidamide, which, unlike acrylamide, readily forms adducts with DNA. Acrylamide cytochrome P450, family 2, subfamily e, polypeptide 1 Mus musculus
2 CYP2E1 metabolises acrylamide to glycidamide, which, unlike acrylamide, readily forms adducts with DNA. Acrylamide cytochrome P450, family 2, subfamily e, polypeptide 1 Mus musculus
3 Thus, to investigate the mechanisms of acrylamide toxicity in mouse male germ cells, we examined the expression of the CYP, CYP2E1, which metabolises acrylamide. Acrylamide cytochrome P450, family 2, subfamily e, polypeptide 1 Mus musculus
4 Thus, to investigate the mechanisms of acrylamide toxicity in mouse male germ cells, we examined the expression of the CYP, CYP2E1, which metabolises acrylamide. Acrylamide cytochrome P450, family 2, subfamily e, polypeptide 1 Mus musculus
5 Additionally, CYP2E1 gene expression was upregulated in these cells following in vitro acrylamide exposure (1 microM, 18 h). Acrylamide cytochrome P450, family 2, subfamily e, polypeptide 1 Mus musculus