Title : Polyamine-blocking therapy reverses immunosuppression in the tumor microenvironment.

Pub. Date : 2014 Mar

PMID : 24778323






1 Functional Relationships(s)
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1 A polyamine-blocking therapy (PBT) that combines the well-characterized ornithine decarboxylase (ODC) inhibitor difluoromethylornithine (DFMO) with AMXT 1501, a novel inhibitor of the polyamine transport system, blocked tumor growth in immunocompetent mice but not in athymic nude mice lacking T cells. Polyamines ornithine decarboxylase, structural 1 Mus musculus