Title : Cancer-associated PTEN mutants act in a dominant-negative manner to suppress PTEN protein function.

Pub. Date : 2014 Apr 24

PMID : 24766807






1 Functional Relationships(s)
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1 Here, we show that PTEN homodimerizes and, in this active conformation, exerts lipid phosphatase activity on PtdIns(3,4,5)P3. phosphatidylinositol 3,4,5-triphosphate phosphatase and tensin homolog Mus musculus