Title : Regulator of G-protein signaling 19 (RGS19) and its partner Gα-inhibiting activity polypeptide 3 (GNAI3) are required for zVAD-induced autophagy and cell death in L929 cells.

Pub. Date : 2014

PMID : 24751948






2 Functional Relationships(s)
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1 The L929 cell death induced by the pan-caspase inhibitor benzyloxycarbonyl-Val-Ala-Asp-(OMe)-fluoromethyl ketone (zVAD) was shown to be an autophagy-mediated death for which RIP1 and RIP3 were both required. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone receptor-interacting serine-threonine kinase 3 Mus musculus
2 By the use of small hairpin RNAs and chemical inhibitors, we further demonstrated that zVAD-induced autophagy requires not only RIP1, RIP3, PI3KC3 and Beclin-1, but also RGS19 and GNAI3, and this autophagy is required for zVAD-induced TNF production. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone receptor-interacting serine-threonine kinase 3 Mus musculus