Pub. Date : 2014 May 16
PMID : 24751519
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | IKK-beta/NF-kappaB p65 mediates p27(Kip1) protein degradation in arsenite response. | arsenite | inhibitor of nuclear factor kappa B kinase subunit beta | Homo sapiens |
| 2 | We here explored the inhibitory regulation of IKKbeta on p27(Kip1) expression following arsenite exposure. | arsenite | inhibitor of nuclear factor kappa B kinase subunit beta | Homo sapiens |
| 3 | Moreover, the results obtained from the comparison of arsenite-induced GSK3beta activation among transfectants of WT, IKKbeta(-/-) and IKKbeta(-/-) (IKKbeta), and the utilization of GSKbeta shRNA, demonstrated that IKKbeta regulation of p27 protein degradation was mediated by GSK3beta following arsenite exposure. | arsenite | inhibitor of nuclear factor kappa B kinase subunit beta | Homo sapiens |