Title : Cholesterol regulates Syntaxin 6 trafficking at trans-Golgi network endosomal boundaries.

Pub. Date : 2014 May 8

PMID : 24746815






1 Functional Relationships(s)
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1 Here, using Chinese hamster ovary (CHO) Niemann-Pick type C1 (NPC1) mutant cell lines and human NPC1 mutant fibroblasts, we show that altered cholesterol levels at the TGN/endosome boundaries trigger Syntaxin 6 (Stx6) accumulation into VAMP3, transferrin, and Rab11-positive recycling endosomes (REs). Cholesterol RAB11A, member RAS oncogene family Homo sapiens