Pub. Date : 2014 Jun 15
PMID : 24740322
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Niclosamide inhibits androgen receptor variants expression and overcomes enzalutamide resistance in castration-resistant prostate cancer. | Niclosamide | androgen receptor | Homo sapiens |
| 2 | CONCLUSIONS: Niclosamide was identified as a novel inhibitor of AR variants. | Niclosamide | androgen receptor | Homo sapiens |
| 3 | Our findings offer preclinical validation of niclosamide as a promising inhibitor of AR variants to treat, either alone or in combination with current antiandrogen therapies, patients with advanced prostate cancer, especially those resistant to enzalutamide. | Niclosamide | androgen receptor | Homo sapiens |