Pub. Date : 2014 Aug
PMID : 24735204
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | FGF21 increases cholesterol efflux by upregulating ABCA1 through the ERK1/2-PPARgamma-LXRalpha pathway in THP1 macrophage-derived foam cells. | Cholesterol | nuclear receptor subfamily 1 group H member 3 | Homo sapiens |
| 2 | In addition, inhibition of ERK1/2 or PPARgamma, or knockdown of LXRalpha attenuated FGF21-mediated promotion of ABCA1 expression and cholesterol efflux. | Cholesterol | nuclear receptor subfamily 1 group H member 3 | Homo sapiens |
| 3 | These results demonstrate that FGF21 can promote cholesterol efflux by upregulating ABCA1 through the ERK1/2-PPARgamma-LXRalpha pathway in THP1 macrophage-derived foam cells. | Cholesterol | nuclear receptor subfamily 1 group H member 3 | Homo sapiens |