Pub. Date : 2014 Apr 30
PMID : 24724627
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Daidzein suppresses tumor necrosis factor-alpha induced migration and invasion by inhibiting hedgehog/Gli1 signaling in human breast cancer cells. | daidzein | tumor necrosis factor | Homo sapiens |
| 2 | In this study, we investigated the role of daidzein in regulating TNF-alpha induced cell invasion and the underlying molecular mechanisms. | daidzein | tumor necrosis factor | Homo sapiens |
| 3 | Daidzein inhibited TNF-alpha induced cellular migration and invasion in estrogen receptor (ER) negative MCF10DCIS.com human breast cancer cells. | daidzein | tumor necrosis factor | Homo sapiens |
| 4 | TNF-alpha activated Hedgehog (Hh) signaling by enhancing Gli1 nuclear translocation and transcriptional activity, which resulted in increased invasiveness; these effects were blocked by daidzein and the Hh signaling inhibitors, cyclopamine and vismodegib. | daidzein | tumor necrosis factor | Homo sapiens |
| 5 | Taken together, mammary tumor cell invasiveness was stimulated by TNF-alpha induced activation of Hh signaling; these effects were abrogated by daidzein, which suppressed Gli1 activation, thereby inhibiting migration and invasion. | daidzein | tumor necrosis factor | Homo sapiens |