Title : Celecoxib exerts protective effects on extracellular matrix metabolism of mandibular condylar chondrocytes under excessive mechanical stress.

Pub. Date : 2014 Jun

PMID : 24721459






2 Functional Relationships(s)
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1 RESULTS: The presence of celecoxib normalized the release of PGE2 and diminished the CTS-induced COX-2, MMP-1, MMP-3, MMP-9 and ADAMTS-5 gene expressions while recovered the downregulated type II collagen and aggrecan gene expressions. Celecoxib matrix metallopeptidase 1 Homo sapiens
2 Concurrently, celecoxib showed inhibition of NF-kappaB and suppression of MMP production and activity. Celecoxib matrix metallopeptidase 1 Homo sapiens