Title : Activation of spinal glucagon-like peptide-1 receptors specifically suppresses pain hypersensitivity.

Pub. Date : 2014 Apr 9

PMID : 24719110






3 Functional Relationships(s)
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1 In addition, intrathecal GLP-1R agonists GLP-1(7-36) and exenatide potently alleviated formalin-, peripheral nerve injury-, bone cancer-, and diabetes-induced hypersensitivity states by 60-90%, without affecting acute nociceptive responses. Exenatide glucagon-like peptide 1 receptor Rattus norvegicus
2 The antihypersensitive effects of exenatide and GLP-1 were completely prevented by GLP-1R antagonism and GLP-1R gene knockdown. Exenatide glucagon-like peptide 1 receptor Rattus norvegicus
3 The antihypersensitive effects of exenatide and GLP-1 were completely prevented by GLP-1R antagonism and GLP-1R gene knockdown. Exenatide glucagon-like peptide 1 receptor Rattus norvegicus