Title : Impaired JNK signaling cooperates with KrasG12D expression to accelerate pancreatic ductal adenocarcinoma.

Pub. Date : 2014 Jun 15

PMID : 24713432






1 Functional Relationships(s)
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1 More specifically, impaired JNK signaling in a subpopulation of Pdx1-expressing cells dramatically accelerated the appearance of Kras(G12D)-induced acinar-to-ductal metaplasia and pancreatic intraepithelial neoplasias, which rapidly progressed to invasive PDAC within 10 weeks of age. pdac pancreatic and duodenal homeobox 1 Homo sapiens