Title : Involvement of the CA1 GABAA receptors in MK-801-induced anxiolytic-like effects: an isobologram analysis.

Pub. Date : 2014 Jun

PMID : 24710315






2 Functional Relationships(s)
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1 An intra-CA1 injection of (+)-MK-801 (2 mug/rat) and muscimol (0.5 mug/rat; a GABAA receptor agonist) increased %OAT and %OAE by themselves while not altering the closed arm entries, indicating an anxiolytic-like effect of these drugs. Muscimol carbonic anhydrase 1 Rattus norvegicus
2 The isobologram analysis of these findings suggested a synergistic anxiety-like effect of intra-CA1 (+)-MK-801 and muscimol. Muscimol carbonic anhydrase 1 Rattus norvegicus