Title : (+)-Nootkatone inhibits tumor necrosis factor α/interferon γ-induced production of chemokines in HaCaT cells.

Pub. Date : 2014 May 2

PMID : 24704449






4 Functional Relationships(s)
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1 We found that (+)-nootkatone inhibited the TNF-alpha/IFN-gamma-induced expression of TARC/CCL17 and MDC/CCL22 mRNA in HaCaT cells. nootkatone C-C motif chemokine ligand 22 Homo sapiens
2 We found that (+)-nootkatone inhibited the TNF-alpha/IFN-gamma-induced expression of TARC/CCL17 and MDC/CCL22 mRNA in HaCaT cells. nootkatone C-C motif chemokine ligand 22 Homo sapiens
3 Taken together, these results suggest that (+)-nootkatone may suppress TNF-alpha/IFN-gamma-induced TARC/CCL17 and MDC/CCL22 expression in HaCaT cells by inhibiting of PKCzeta and p38 MAPK signaling pathways that lead to activation of NF-kappaB. nootkatone C-C motif chemokine ligand 22 Homo sapiens
4 Taken together, these results suggest that (+)-nootkatone may suppress TNF-alpha/IFN-gamma-induced TARC/CCL17 and MDC/CCL22 expression in HaCaT cells by inhibiting of PKCzeta and p38 MAPK signaling pathways that lead to activation of NF-kappaB. nootkatone C-C motif chemokine ligand 22 Homo sapiens