Title : Genetic variants of IgG1 antibodies and FcγRIIIa receptors influence the magnitude of antibody-dependent cell-mediated cytotoxicity against prostate cancer cells.

Pub. Date : 2014 Jan 1

PMID : 24701371






1 Functional Relationships(s)
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1 Of note, the ADCC-inhibitory effect of the same IgG1 molecules was significantly reduced when NK cells expressed phenylalanine-containing FcgammaRIIIa (93% vs. 50%; P = 0.0000005). Phenylalanine Fc gamma receptor IIIa Homo sapiens