Pub. Date : 2014 Jun
PMID : 24696042
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | We postulated that MC histamine H4-receptors (H4Rs), being Galphai/o-coupled, might activate a protein kinase C isotype-epsilon (PKCepsilon)-aldehyde dehydrogenase type-2 (ALDH2) cascade, ultimately eliminating MC-degranulating and renin-releasing effects of aldehydes formed in I/R and associated arrhythmias. | Aldehydes | protein kinase C epsilon | Homo sapiens |
2 | We found that activation of MC H4Rs mimics the cardioprotective anti-RAS effects of IPC and that protection depends on the sequential activation of PKCepsilon and ALDH2 in MCs, reducing aldehyde-induced MC degranulation and renin release and alleviating reperfusion arrhythmias. | Aldehydes | protein kinase C epsilon | Homo sapiens |