Title : Histamine H4-receptors inhibit mast cell renin release in ischemia/reperfusion via protein kinase C ε-dependent aldehyde dehydrogenase type-2 activation.

Pub. Date : 2014 Jun

PMID : 24696042






2 Functional Relationships(s)
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1 We postulated that MC histamine H4-receptors (H4Rs), being Galphai/o-coupled, might activate a protein kinase C isotype-epsilon (PKCepsilon)-aldehyde dehydrogenase type-2 (ALDH2) cascade, ultimately eliminating MC-degranulating and renin-releasing effects of aldehydes formed in I/R and associated arrhythmias. Aldehydes protein kinase C epsilon Homo sapiens
2 We found that activation of MC H4Rs mimics the cardioprotective anti-RAS effects of IPC and that protection depends on the sequential activation of PKCepsilon and ALDH2 in MCs, reducing aldehyde-induced MC degranulation and renin release and alleviating reperfusion arrhythmias. Aldehydes protein kinase C epsilon Homo sapiens